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Inosine enhances the efficacy of immune-checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study

Suzuki N, Shinden S, Oishi N, Ueno M, Suzuki D, Ogawa K, Ozawa H

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So far, recent research has revealed that GPR81 regulates multiple signal pathways in tissues and cells, such as the extracellular regulated protein kinases (ERK1/2) (7, 180182), nod-like receptor family pyrin domain-containing 3 (NLRP3)/ nuclear factor kappa-B (NF-B) inflammation (183, 184), peroxisome proliferator-activated receptor (PPAR) (185, 186) and Wnt signaling pathway (187, 188)

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